Acceleration of nerve and muscle regeneration by administration of nucleotides – electroneurophysiological and morphometrical investigations. 13 Wattig B, Schalow G, Madauss M, Heydenreich F, Warzok R, Cervós-Navarro J.Electrophysiologic and morphometric investigations. Enhancement of nerve fibre regeneration by nucleotides after peripheral nerve crush damage. 12 Wattig B, Schalow G, Heydenreich F, Warzok R, Cervós-Navarro J.Neural plasticity after peripheral nerve injury and regeneration. The burden of neuropathic pain: results from a cross-sectional survey. 9 McDermott AM, Toelle TR, Rowbotham DJ, Schaefer CP, Dukes EM.A prospective identification of neuropathic pain in specific polyneuropathy syndromes and response to pharmacological therapy. Intensive evaluation of referred unclassified neuropathies yields improved diagnosis. Clinical effectiveness and cost-effectiveness of treatments for patients with chronic pain. Clinical characteristics and economics costs of patients with painful neuropathic disorders. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy and neuropathy in a population-based cohort: the Rochester Diabetic Neuropathy Study. Dick PJ, Thomas PK, Griffin JW, Low PA, Poduslo JF (Eds). 3 Peripheral Neuropathy (3rd Edition).Furthermore, it makes it possible to reduce the dosage of concomitant medication. It leads to statistically significant reductions not only in the total PDQ score but also in the intensity of pain, number of areas affected, and pain radiation. Conclusions: The combination of UMP+folic acid+vitamin B 12 is effective against NeP associated with PN. Nonsteroidal anti-inflammatory drugs were decreased/withdrawn in 77.4% of patients. The global score for pain assessed using PDQ decreased from 17.5 points to 8.8 points at the final evaluation (p<0.001). Results: The intensity of the NeP assessed at the time of the consultation progressed favorably and decreased significantly (p<0.001) in all the types of PN included. Pain was assessed using the painDETECT questionnaire (PDQ). Patients and Methods: We performed an exploratory, open-label, multicenter, study of 212 patients followed for 2 months. Our objective was to evaluate clinical improvement in patients with PN and NeP treated with a combination of UMP+folic acid+vitamin B 12 (Keltican ®). Nucleotides such as uridine monophosphate (UMP) have proven to be efficacious in treating the cause of the myelin sheath lesion in several experimental and clinical models. Regeneration/protection of the myelin sheath after a nerve lesion is a fundamental element of repair in PN. The pathophysiology of PN is characterized by lesions of myelin-producing Schwann cells in peripheral nerves. Neuropathic pain (NeP) has a significant incidence in the general population and affects more than half of all patients with PN. Aims: Peripheral neuropathy (PN) is a common condition whose incidence is approximately 8% in elderly persons.
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